Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin.
Identifieur interne : 000467 ( Main/Exploration ); précédent : 000466; suivant : 000468Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin.
Auteurs : Elide A. Pastorello [Italie] ; Laura Farioli ; Valerio Pravettoni ; Claudio Ortolani ; Donatella Fortunato ; Maria Gabriella Giuffrida ; Lorenza Perono Garoffo ; Ambra Marianna Calamari ; Oreste Brenna ; Amedeo ContiSource :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Allergènes (composition chimique), Allergènes (isolement et purification), Antigènes végétaux (MeSH), Chitinase (immunologie), Données de séquences moléculaires (MeSH), Femelle (MeSH), Humains (MeSH), Hypersensibilité alimentaire (immunologie), Hypersensibilité alimentaire (étiologie), Immunoglobuline E (sang), Immunotransfert (MeSH), Mâle (MeSH), Protéines de transport (immunologie), Protéines végétales (immunologie), Réactions croisées (MeSH), Spectrométrie de masse ESI (MeSH), Séquence d'acides aminés (MeSH), Vin (analyse), Vin (effets indésirables), Vitis (composition chimique), Vitis (effets indésirables), Vitis (immunologie), Édulcorants (MeSH).
- MESH :
- analyse : Vin.
- composition chimique : Allergènes, Vitis.
- effets indésirables : Vin, Vitis.
- immunologie : Chitinase, Hypersensibilité alimentaire, Protéines de transport, Protéines végétales, Vitis.
- isolement et purification : Allergènes.
- sang : Immunoglobuline E.
- étiologie : Hypersensibilité alimentaire.
- Adulte, Adulte d'âge moyen, Antigènes végétaux, Données de séquences moléculaires, Femelle, Humains, Immunotransfert, Mâle, Réactions croisées, Spectrométrie de masse ESI, Séquence d'acides aminés, Édulcorants.
English descriptors
- KwdEn :
- Adult (MeSH), Allergens (chemistry), Allergens (isolation & purification), Amino Acid Sequence (MeSH), Antigens, Plant (MeSH), Carrier Proteins (immunology), Chitinases (immunology), Cross Reactions (MeSH), Female (MeSH), Food Hypersensitivity (etiology), Food Hypersensitivity (immunology), Humans (MeSH), Immunoblotting (MeSH), Immunoglobulin E (blood), Male (MeSH), Middle Aged (MeSH), Molecular Sequence Data (MeSH), Plant Proteins (immunology), Spectrometry, Mass, Electrospray Ionization (MeSH), Sweetening Agents (MeSH), Vitis (adverse effects), Vitis (chemistry), Vitis (immunology), Wine (adverse effects), Wine (analysis).
- MESH :
- chemical , blood : Immunoglobulin E.
- chemical , chemistry : Allergens.
- chemical , immunology : Carrier Proteins, Chitinases, Plant Proteins.
- chemical , isolation & purification : Allergens.
- adverse effects : Vitis, Wine.
- analysis : Wine.
- chemistry : Vitis.
- etiology : Food Hypersensitivity.
- immunology : Food Hypersensitivity, Vitis.
- Adult, Amino Acid Sequence, Antigens, Plant, Cross Reactions, Female, Humans, Immunoblotting, Male, Middle Aged, Molecular Sequence Data, Spectrometry, Mass, Electrospray Ionization, Sweetening Agents.
Abstract
BACKGROUND
Few allergic reactions to grape are reported in the literature. In some cases an association with peach and cherry allergy was observed. No IgE-mediated reactions to wine have been described, and no grape major allergens have yet been identified.
OBJECTIVE
We describe several severe reactions to grape or wine. We characterized the grape major allergens and tried to identify the allergen in wine.
METHODS
We collected documented histories of allergic reactions to grape and wine. Grape allergens were identified by means of SDS-PAGE and immunoblotting and purified by means of HPLC. Using amino acid sequencing and mass spectrometry, we identified the family of proteins to which the allergens belong. Cross-reactivity with peach and cherry was evaluated by means of cross-wise inhibition experiments.
RESULTS
Eleven patients with reactions to grape and 3 with anaphylactic reactions to wine were recruited. The major allergens were an endochitinase 4A and a lipid-transfer protein (LTP) that was homologous to and cross-reactive with peach LTP. A 24-kd protein homologous to the cherry thaumatin-like allergen was a minor allergen. Endochitinase 4A is very likely the allergen in vino novello and in vino Fragolino.
CONCLUSIONS
Grape and wine might cause severe allergic reactions in sensitive patients. The major allergens of grape are endochitinase 4A, which is also the allergen of wine, and an LTP cross-reacting with the peach major allergen.
DOI: 10.1067/mai.2003.35
PubMed: 12589356
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Pastorello</name><affiliation wicri:level="1"><nlm:affiliation>Allergy Center, First Division of General Medicine, Ospedale Maggiore IRCCS, Via Francesco Sforza 35, 20122 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Allergy Center, First Division of General Medicine, Ospedale Maggiore IRCCS, Via Francesco Sforza 35, 20122 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Farioli, Laura" sort="Farioli, Laura" uniqKey="Farioli L" first="Laura" last="Farioli">Laura Farioli</name></author><author><name sortKey="Pravettoni, Valerio" sort="Pravettoni, Valerio" uniqKey="Pravettoni V" first="Valerio" last="Pravettoni">Valerio Pravettoni</name></author><author><name sortKey="Ortolani, Claudio" sort="Ortolani, Claudio" uniqKey="Ortolani C" first="Claudio" last="Ortolani">Claudio Ortolani</name></author><author><name sortKey="Fortunato, 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(MeSH)</term><term>Vitis (adverse effects)</term><term>Vitis (chemistry)</term><term>Vitis (immunology)</term><term>Wine (adverse effects)</term><term>Wine (analysis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allergènes (composition chimique)</term><term>Allergènes (isolement et purification)</term><term>Antigènes végétaux (MeSH)</term><term>Chitinase (immunologie)</term><term>Données de séquences moléculaires (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hypersensibilité alimentaire (immunologie)</term><term>Hypersensibilité alimentaire (étiologie)</term><term>Immunoglobuline E (sang)</term><term>Immunotransfert (MeSH)</term><term>Mâle (MeSH)</term><term>Protéines de transport (immunologie)</term><term>Protéines végétales (immunologie)</term><term>Réactions croisées (MeSH)</term><term>Spectrométrie de masse ESI (MeSH)</term><term>Séquence d'acides aminés (MeSH)</term><term>Vin (analyse)</term><term>Vin (effets indésirables)</term><term>Vitis (composition chimique)</term><term>Vitis (effets indésirables)</term><term>Vitis (immunologie)</term><term>Édulcorants (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Allergens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Carrier Proteins</term><term>Chitinases</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Allergens</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Vitis</term><term>Wine</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Vin</term></keywords><keywords scheme="MESH" qualifier="analysis" 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xml:lang="fr"><term>Immunoglobuline E</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hypersensibilité alimentaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Amino Acid Sequence</term><term>Antigens, Plant</term><term>Cross Reactions</term><term>Female</term><term>Humans</term><term>Immunoblotting</term><term>Male</term><term>Middle Aged</term><term>Molecular Sequence Data</term><term>Spectrometry, Mass, Electrospray Ionization</term><term>Sweetening Agents</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes végétaux</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Humains</term><term>Immunotransfert</term><term>Mâle</term><term>Réactions croisées</term><term>Spectrométrie de masse ESI</term><term>Séquence d'acides aminés</term><term>Édulcorants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Few allergic reactions to grape are reported in the literature. In some cases an association with peach and cherry allergy was observed. No IgE-mediated reactions to wine have been described, and no grape major allergens have yet been identified.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>We describe several severe reactions to grape or wine. We characterized the grape major allergens and tried to identify the allergen in wine.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We collected documented histories of allergic reactions to grape and wine. Grape allergens were identified by means of SDS-PAGE and immunoblotting and purified by means of HPLC. Using amino acid sequencing and mass spectrometry, we identified the family of proteins to which the allergens belong. Cross-reactivity with peach and cherry was evaluated by means of cross-wise inhibition experiments.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Eleven patients with reactions to grape and 3 with anaphylactic reactions to wine were recruited. The major allergens were an endochitinase 4A and a lipid-transfer protein (LTP) that was homologous to and cross-reactive with peach LTP. A 24-kd protein homologous to the cherry thaumatin-like allergen was a minor allergen. Endochitinase 4A is very likely the allergen in vino novello and in vino Fragolino.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Grape and wine might cause severe allergic reactions in sensitive patients. The major allergens of grape are endochitinase 4A, which is also the allergen of wine, and an LTP cross-reacting with the peach major allergen.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12589356</PMID><DateCompleted><Year>2003</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0091-6749</ISSN><JournalIssue CitedMedium="Print"><Volume>111</Volume><Issue>2</Issue><PubDate><Year>2003</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of allergy and clinical immunology</Title><ISOAbbreviation>J Allergy Clin Immunol</ISOAbbreviation></Journal><ArticleTitle>Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin.</ArticleTitle><Pagination><MedlinePgn>350-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Few allergic reactions to grape are reported in the literature. In some cases an association with peach and cherry allergy was observed. No IgE-mediated reactions to wine have been described, and no grape major allergens have yet been identified.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We describe several severe reactions to grape or wine. We characterized the grape major allergens and tried to identify the allergen in wine.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We collected documented histories of allergic reactions to grape and wine. Grape allergens were identified by means of SDS-PAGE and immunoblotting and purified by means of HPLC. Using amino acid sequencing and mass spectrometry, we identified the family of proteins to which the allergens belong. Cross-reactivity with peach and cherry was evaluated by means of cross-wise inhibition experiments.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eleven patients with reactions to grape and 3 with anaphylactic reactions to wine were recruited. The major allergens were an endochitinase 4A and a lipid-transfer protein (LTP) that was homologous to and cross-reactive with peach LTP. A 24-kd protein homologous to the cherry thaumatin-like allergen was a minor allergen. Endochitinase 4A is very likely the allergen in vino novello and in vino Fragolino.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Grape and wine might cause severe allergic reactions in sensitive patients. The major allergens of grape are endochitinase 4A, which is also the allergen of wine, and an LTP cross-reacting with the peach major allergen.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pastorello</LastName><ForeName>Elide A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Allergy Center, First Division of General Medicine, Ospedale Maggiore IRCCS, Via Francesco Sforza 35, 20122 Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farioli</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Pravettoni</LastName><ForeName>Valerio</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ortolani</LastName><ForeName>Claudio</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Fortunato</LastName><ForeName>Donatella</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Giuffrida</LastName><ForeName>Maria Gabriella</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Perono Garoffo</LastName><ForeName>Lorenza</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Calamari</LastName><ForeName>Ambra Marianna</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Brenna</LastName><ForeName>Oreste</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Conti</LastName><ForeName>Amedeo</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Allergy Clin Immunol</MedlineTA><NlmUniqueID>1275002</NlmUniqueID><ISSNLinking>0091-6749</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000485">Allergens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052179">Antigens, Plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013549">Sweetening Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C511920">lipid transfer proteins, plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>37341-29-0</RegistryNumber><NameOfSubstance UI="D007073">Immunoglobulin E</NameOfSubstance></Chemical><Chemical><RegistryNumber>53850-34-3</RegistryNumber><NameOfSubstance UI="C003427">thaumatin protein, plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.14</RegistryNumber><NameOfSubstance UI="D002688">Chitinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000485" MajorTopicYN="N">Allergens</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D052179" MajorTopicYN="N">Antigens, Plant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002688" MajorTopicYN="N">Chitinases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005512" MajorTopicYN="N">Food Hypersensitivity</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015151" MajorTopicYN="N">Immunoblotting</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007073" MajorTopicYN="N">Immunoglobulin E</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021241" MajorTopicYN="N">Spectrometry, Mass, Electrospray Ionization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013549" MajorTopicYN="N">Sweetening Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027843" MajorTopicYN="N">Vitis</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014920" MajorTopicYN="N">Wine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>2</Month><Day>18</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>3</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>2</Month><Day>18</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12589356</ArticleId><ArticleId IdType="doi">10.1067/mai.2003.35</ArticleId><ArticleId IdType="pii">S0091674902912972</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Brenna, Oreste" sort="Brenna, Oreste" uniqKey="Brenna O" first="Oreste" last="Brenna">Oreste Brenna</name><name sortKey="Calamari, Ambra Marianna" sort="Calamari, Ambra Marianna" uniqKey="Calamari A" first="Ambra Marianna" last="Calamari">Ambra Marianna Calamari</name><name sortKey="Conti, Amedeo" sort="Conti, Amedeo" uniqKey="Conti A" first="Amedeo" last="Conti">Amedeo Conti</name><name sortKey="Farioli, Laura" sort="Farioli, Laura" uniqKey="Farioli L" first="Laura" last="Farioli">Laura Farioli</name><name sortKey="Fortunato, Donatella" sort="Fortunato, Donatella" uniqKey="Fortunato D" first="Donatella" last="Fortunato">Donatella Fortunato</name><name sortKey="Giuffrida, Maria Gabriella" sort="Giuffrida, Maria Gabriella" uniqKey="Giuffrida M" first="Maria Gabriella" last="Giuffrida">Maria Gabriella Giuffrida</name><name sortKey="Ortolani, Claudio" sort="Ortolani, Claudio" uniqKey="Ortolani C" first="Claudio" last="Ortolani">Claudio Ortolani</name><name sortKey="Perono Garoffo, Lorenza" sort="Perono Garoffo, Lorenza" uniqKey="Perono Garoffo L" first="Lorenza" last="Perono Garoffo">Lorenza Perono Garoffo</name><name sortKey="Pravettoni, Valerio" sort="Pravettoni, Valerio" uniqKey="Pravettoni V" first="Valerio" last="Pravettoni">Valerio Pravettoni</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Pastorello, Elide A" sort="Pastorello, Elide A" uniqKey="Pastorello E" first="Elide A" last="Pastorello">Elide A. Pastorello</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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